This text in 1 Thessalonians 5:23: Now may the God of peace himself sanctify you completely, and may your whole spirit and soul and body be kept blameless at the coming of our Lord Jesus Christ; it refers to the second coming of Christ, the parousia; and the biblical triple division of man: body, soul and spirit.
The soul is the perfection of the body and the spirit is the divine substance, thence the difference between virtues and spiritual gifts and the difference between the love of the soul and the love of the spirit (Agape, Love of Charity). Do not confuse the threefold biblical division: body, soul and spirit; with the Greek division of the soul: reason, passion and desire.
When we speak about the spirit we speack about love as friendship, not as a concupiscence, is to talk about human nature, the adult and integral man. This calls us not to act by fear or greed but as true friends of God. When we talk about soul we speak about the faculties of imagination and fantasy, but the man as such requires the faculties of the spirit: intuition, inspiration, creativity and empathy. We live in times where the fantasy of success and power are exacerbated and we work a little bit or not, the faculties of creavity and empathy. We act using the faculties of the soul and too little the faculties of the spirit.
We are experiencing a crisis of creativity and this is the criticism that is heard frequently, but creativity requires risks, you can not be creative and not be a threat to those who want to live in a static and unchanged word. Be creative, empathic and intuitive means to be spiritual. Talk about spirituality is to talk about these faculties, the rest is superficial. Being rational men involves being subject to reason and the fantasy of our ego and systematically deny all that we dislike. As if fantasy could be stronger than the reality around us. Being natural men instead is consider madness and follishness everything that makes us excellent, better people and friends of God. We follow the divine, our own excellences or we live slaves of our own mistakes. We choose.